Pineapple Express is a sativa-dominant hybrid marijuana strain made by crossing Trainwreck with Hawaiian. While this strain rose to fame on the silver screen in 2008 amidst the release of Pineapple Express, it is a real strain that you can find on the shelves of dispensaries across the country.  Since then, this strain has become a favorite in the hearts and minds of cannabis lovers.  Pineapple Express is 18% THC and may make you feel buzzy, alert, and creative. The best time to smoke Pineapple Express is in the morning, afternoon, or early evening hours.